This is the wicked problem. While medical research has made such a spectacular impact on communicable disease, we are struggling when it comes to non-communicable disease. We face rising rates of diabetes, heart disease, obesity and mental ill-health, with ever-closer connections between them. We have been very good at describing the causes of these diseases, but less successful at coming up with solutions. Almost 90% of our health research funding is invested in biomedical research hoping to find new molecular or genetic cures, but paradoxically almost 90% of the determinants of health are social and environmental.