Bradford is the fifth largest city in the UK and has some of the highest levels of poverty and ill-health. It is ethnically diverse, with a large South Asian community and a rising prevalence of diabetes and cardiovascular disease. Researchers working with policymakers have developed Bradford as a City of Research, building strong networks across health care providers and schools, connecting multiple systems and developing whole system information and analytic capacity. We have worked closely with our communities to promote a strong public voice in the focus and delivery of research and now have a population based, system wide research infrastructure with committed investment to support the delivery of interdisciplinary preventative interventions. Tower Hamlets has some of the highest rates of child poverty in the UK which has driven the development of a strong foundation of community-developed research, in particular through the Communities Driving Change programme and transformative community health models developed by the Bromley-by-Bow Centre. Tower Hamlets Council has demonstrated enthusiasm and commitment for ActEarly and offers an existing platform of linked routine data through the Whole Systems Data Integration programme.